[3] Multiple businesses have occupied the building over its lifetime, including banks, insurance companies, and a dentist.

Two of the buildings that remain standing are listed on the National Register of Historic Places, a Craftsman Style house now known as the William Swain House, at 315 West Main Street, about two blocks west of the Flatiron,[6] and the Greystone Church, originally the New Presbyterian Church, which is located at 430 NE Maple Street.

In the beginning, the front office was used by Grain Companies, Pullman Savings and Loan, and Farmers State Bank.

More recently, State Farm Insurance occupied the front office, from 1957 into the 1990s and was commonly associated with the Flatiron Building, and being located on such a prominent corner.

[8] Dr. Low's dental office was located on the upper floor of the Flatiron building for a period of time as well.

[10][failed verification] Selene Santucci set up an art studio on the second floor and became a permanent resident of the Flatiron Building.

[14] With these exceptions, Swindal chose to restore the façade as accurately as possible, to maintain the original historic look the building, including some use of intact bricks salvaged from the rubble.

[8] The resulting restoration can be seen in the 2010 photo above, however it is clear that the brickwork at the front does not match the original tapestry brick of the rest of the building.