World's Greatest Heroes is not directly connected to any of the previous iterations of the Fantastic Four, telling its own version of the team's origin and their encounters with their rogues gallery.

Unlike its 1994 predecessor, which consisted almost entirely of straight or modified reinterpretations of classic Fantastic Four comic book stories, World's Greatest Heroes features mostly original stories, though elements from various comic iterations of the Fantastic Four were used in the series.

In October 2004, it was announced Marvel Studios and MoonScoop Group would be teaming up to produce an animated series based on the Marvel Comics' Fantastic Four comic book series which would be shopped to potential buyers.

He finds himself in a stadium filled with aliens, where he has been put on trial for crimes against the Kree Empire, with Ronan the Accuser acting as judge.

Ben, Sue, and Reed fight the robot executioners, one of which is accidentally thrown into the crowd.