[4] Gifted teenager Peter Parker is given superpowers when he is bitten by a radioactive spider during a school field trip to Oscorp Industries.

Sometime later, Peter begins learning how to balance his crime-fighting career with his new enrollment at Horizon High, a school for students with genius-level intellect run by Max Modell.

[1] Besides Norman and Jackal, other villains introduced this season include Doctor Octopus, Vulture, Venom, Rhino, Spencer and Alistair Smythe, Kraven the Hunter, Black Cat, A.I.M., Curt Connors, Sandgirl, Scorpion, and Crossbones.

This season introduces more villains, including Chameleon, Electro, Silvermane, Regent, Beetle, Silver Sable, Tinkerer, Monica Rappaccini, MODOK, Slyde, Eddie Brock, and the Wake Riders.

During the battle with the Klyntar, Horizon High is destroyed, after which the Spiders form a tech laboratory called the Worldwide Engineering Brigade to replace it.

Besides Dark Goblin, other villains introduced in this season include Scream, Scorn, Mania, Swarm (Jefferson Davis), Tarantula, Baron Mordo, and the Klyntar dragon Grendel.

Other characters introduced in this season include Ironheart, the Totally Awesome Hulk, Doctor Strange, Star-Lord, Groot, Moon Knight, Anti-Venom, and Thor.