Pythium graminicola infects a wide range of hosts, including: bent grass, turmeric, cotton, barley, wheat, rice, beans, peas, and sugarcane.

The oospores that infect plants then create sporangia, the asexual state of Pythium graminicola, which acts as a secondary innoculum, making the disease cycle polycyclic.

Penetration occurs quickly, and the cell wall does not act as an important barrier to keep Pythium graminicola from infecting the plant.

Chemical control involves using specific pesticides such as benomyl, captafol, captan, carboxin, metalaxyl, propamocarb hydrochloride, and etridiazole to try and kill surviving oospores in the soil.

Biological control involves using microorganisms that protect the plant roots by producing antifungal metabolites and competing with the pathogen for nutrients.