Pyxine lyei is a species of saxicolous (rock-dwelling), foliose lichen in the family Caliciaceae.

Found in East Africa, it was scientifically described as a new species in 1975 by lichenologists Dougal Swinscow and Hildur Krog.

[1] The lichen has a whitish thallus that is tightly appressed to its substrate.

The lobes comprising the thallus are flat, and have faint pseudocyphellae (tiny pores for air exchange) as well as patches of pruina.

[2] Pyxine lyei is only known to occur in Uganda and Kenya, where it is locally common on fully exposed rocks in hot and dry places, typically at elevations ranging between 1,200 to 1,900 m (3,900 to 6,200 ft).