Quaker Run is a tributary of Shamokin Creek in Northumberland County, Pennsylvania, in the United States.

Quaker Run is designated as an impaired waterbody due to metals from abandoned mine drainage.

It flows southwest for a short distance and crosses Pennsylvania Route 61 before turning west-southwest for more than a mile and entering Mount Carmel Township and a valley.

The stream then turns in a westerly direction for a few miles, entering Coal Township and then the census-designated place of Ranshaw.

In Ranshaw, it crosses Pennsylvania Route 901 and reaches its confluence with Shamokin Creek.

[1] Quaker Run joins Shamokin Creek 24.68 miles (39.72 km) upstream of its mouth.

[4] The entirety of Quaker Run is designated as impaired due to metals and siltation from abandoned mine drainage.

[3] Wal-Mart Stores Inc. has an NPDES permit to discharge stormwater into the stream in Coal Township.

Near Kulpmont, the discharge was 2 cubic feet per second (0.057 m3/s) and the specific conductance was 619 micro-siemens per centimeter at 25 °C (77 °F).

[2] The mouth of the stream is in the United States Geological Survey quadrangle of Shamokin.

[9] The Wildlife for Everyone Endowment Foundation has carried out a restoration project on Quaker Run in Coal Township.

This project has restored 2,000 feet (610 m) of stream and created 3 acres (1.2 ha) of wetlands.

[13] Quaker Run was entered into the Geographic Names Information System on August 2, 1979.

[9] In 1790, Isaac Tomlinson discovered black stones in Quaker Run, which flowed through his property.

[18] The Northumberland County Conservation District has also received a $79,000 Growing Greener grant to carry out a feasibility study for restoring the stream.

A flood control project for the stream is scheduled to begin in 2016, with new channel walls being planned for April of that year.