A strong typhoon destroyed the convent on September 26, 1905, that forced the school to be transferred to a building on Granja Street.

When Japanese atrocities reached Atimonan, Quezon on December 23, 1941, students continued to flock to Tayabas High School and were automatically promoted.

The formal liberation of Tayabas Province on April 4, 1945, after which classes opened at Lucena Catholic Hall (now Maryhill College Building).

In June 1945, the high school was relocated at the Tayabas Provincial Capitol and the Court of First Instance Building, whereby 54 students graduated, girls in Balintawak and boys in Barong Tagalog on July 28, 1945.

The Alma mater of the Quezon National High School has the same tune as the Italian fascist song, Giovinezza.

But not even that 1972 feat produced as many group medals as the big haul of the 1977 edition, which had Marie Delicia T. Unson as adviser; Normita Atienza, co-adviser; and Ricardo J. Cueto, Jr. as editor-in-chief.

That year, The Coconut and The Pine Tree of Baguio so dominated the competitions they practically split the top group honors just between them.

The publication celebrated its 75th anniversary in 2003 where previous and present staff writers and advisers joined together to party.

Currently, the adviser of The Coconut and Ang Niyog is Abner Pureza with co-adviser Maria Aluinda Puno with Ramonito Elumbaring, Mark John Ayuso, Arlene Aurin and Vanessa Ellaga.

Since its implementation, this rigorous curriculum has continued to produce quality STEM-education for Quezon National High School students.

In 2019, Nathaniel Reyes, a student from QNHS and an alumnus of the school's STE program, represented the Philippines at the Intel International Science and Engineering Fair (ISEF) in the United States.

These will make up 15 core courses with the same contents and competencies but with allowed contextualization based on school's location despite specializations of tracks and strands.