Near the Paso de las Carreteras dam, the Quinto River begins to flow through the Pampas.

It passes Villa Mercedes city, where it is about 45 metres (148 ft) wide.

Finally, it flows into the Bañados de la Amarga swamps in its lower course.

During the rainy season the Quinto's waters sometimes rise sufficiently to reach Santa Fé and Buenos Aires provinces and sometimes even as far as the Salado River basin.

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