The R80 is a provincial route in the City of Tshwane Metropolitan Municipality in Gauteng, South Africa that connects the Pretoria CBD with Mabopane and Soshanguve.

It is a dual carriageway freeway, with 2 or 3 lanes in each direction at different points and is named the Mabopane Highway.

It passes through the Theo Martins Gateway (Afrikaans:Theo Martins Poort), a mountain pass over the Magaliesberg mountains, and the northbound carriageway has a rising hairpin bend, approaching the pass, as the freeway abruptly switches from an east-west to a south–north direction.

[1] Proceeding northwards, the R80 meets the R513 road before forming an interchange with the N4 national route (Northern Pretoria Bypass; Platinum Highway) in Akasia.

[1] The highway proceeds northwards to meet the R566 road at an off-ramp just east of Rosslyn and proceeds to end at a junction with the M39 road of Tshwane in Soshanguve, with the M39 providing access to Mabopane (which is just west of Soshanguve).