The R566 is a Regional Route in South Africa that connects Brits with Pretoria North via Ga-Rankuwa and Rosslyn.

Its western terminus is a junction with the R104 route about 10 kilometres east of Modderspruit (5.5 kilometres west of The Elephant Sanctuary Hartbeespoort Dam) in the Madibeng Local Municipality of the North West Province.

It proceeds east-north-east for 3.6 kilometres, crossing the Crocodile River, to reach a junction with the R511 route south-east of the town centre.

[1] From the R80 interchange, the R566 heads south-east, bypassing the Onderstepoort Private Nature Reserve, to cross back to the southern side of the N4 highway (Platinum Highway; Pretoria Northern Bypass) and pass just north of the Pretoria North suburb.

It meets the northern terminus of the M1 route (Paul Kruger Street; which connects to Pretoria North and the Pretoria CBD) before ending at an intersection with the R101 route at Annlin, just south of the Wonderboom Airport entrance.