Within the first week of the season, Reilly entered into a romantic relationship with fellow houseguest Brendon Villegas, leading to the pair becoming immediate targets.

Despite being nominated in the first week, Reilly was spared when the rest of the house decided fellow nominee Annie Whittington was a bigger threat.

Reilly won two Head of Household competitions during her stay in the house, in the second and fourth weeks, resulting in the evictions of Monet Stunson and Kristen Bitting.

As a result of her ninth place finish, Reilly became the first member of the Big Brother jury, and eventually voted for runner-up Lane Elenburg to win the $500,000 prize.

However, Daniele then proceeded to win the next HoH competition, nominating Reilly and Villegas against each other, sparking a long-running feud between the two women.

Reilly was nominated again the following week, but was spared when confusion about an upcoming twist caused Lawon Exum to volunteer to be evicted in her place, in the mistaken belief that it would give him an advantage in the game.

After narrowly surviving an eviction vote 3-2 against Schroeder, Reilly paired with Lloyd when the duos twist briefly returned, and won a key Veto competition that kept them both in the game at the expense of Shelly Moore.

She is also tied with Drew Daniel, Pierzina, Hayden Moss, Ian Terry, Aaryn Gries and Caleb Reynolds for the most sole HOHs won in a season at four.

In late 2011, photographs appeared on the internet suggesting that Reilly and Villegas are competing as a team on season 20 of The Amazing Race.

[10] In 2013, Reilly began appearing in a Hollywood production of The Real Drunk Housewives of San Fernando Valley, a musical parody of the television show.

They ended up in 3rd place out of 11 teams in the final leg, losing to border patrol agents of Art Velez and J.J. Carrell (runners-up) and the married couple Rachel and Dave Brown, Jr. (winners).

They were immersed in a giant water tank upside down by their ankles to test their fear of drowning and how long they could handle the task.

[15] Reilly competed against fellow Big Brother and The Amazing Race alum Janelle Pierzina and former Survivor contestants Cirie Fields and Stephenie Lagrossa Kendrick for a chance to win $100,000.

At the end of the episode, she, Pierzina, and Fields figured out that LaGrossa Kendrick was the Snake and the three of them split the grand prize money.

[16][17][18] In 2023, Reilly competed on Peacock's reality TV series The Traitors alongside her fellow Snake in the Grass contestants Cirie Fields and Stephenie LaGrossa Kendrick.

[19] Reilly has played a recurring role as a waitress on CBS's Emmy Award-winning soap opera The Bold and the Beautiful since 2010.