The nerve lesions in these people show dissemination in space with an otherwise normal neurological examination and without historical accounts of typical MS symptoms.
[5] Currently, routine clinical follow-up and MRI neuroimaging surveillance is the standard by which patients are observed.
[9] Though rare, some children that have had MRI scans for reasons unrelated to MS have shown signs of RIS.
The presence of oligoclonal bands in the CSF and spinal cord lesions were associated with an increased risk of a first clinical event characteristic of MS.
It was found that children with RIS had a substantial risk of subsequent clinical symptoms and/or radiologic evolution.