[citation needed] Her mother, Kaamini Khanna is a writer, music director, singer, anchor and founder of 'Beauty with Astrology'.

[5] Ragini is the granddaughter of classical singer Nirmala Devi and popular 1940s actor Arun Kumar Ahuja.

[7] Khanna made her acting debut with the daily soap opera Radhaa Ki Betiyaan Kuch Kar Dikhayengi on NDTV Imagine as "Ragini Sharma".

[10] She was also seen as a guest in Imagine TV's reality show Big Money: Chota Parda Bada Game.

[11][12][13] She played the lead role as Suhana Kashyap, an arrogant, but good at heart woman who marries a man of a middle class joint family.

Her portrayal as Suhana won her some awards including BIG Star Most Entertaining Television Actor - Female.

[17] In 2011, Khanna participated in a celebrity singing reality show Star Ya Rockstar on Zee TV.

[25] Khanna was termed as the "Next Big Thing" on Television by JD Majethia, Varun Badola and Rajan Shahi, in a Hindustan Times poll.

[32] In 2011, she hosted the music launch of Ra.One, a Bollywood science-fiction starring Shah Rukh Khan and Kareena Kapoor.

They have also launched an early morning spiritual and wellness radio show titled 'Seher' on 92.7 BIG FM with Khanna as the brand ambassador.

[36] In 2010, Khanna was roped in as judge in Frito-Lay India's consumer campaign titled "Kurkure Spend Time with Family".