Ramón López de Osornio (31 August 1685 – 1757) was a Spanish landowner and military man who served as commander of provincial militias during the colonial period of Argentina.

[1] He owned farms in the towns of La Matanza[2] and Magdalena, where he dedicated himself to raising cattle.

[3] He was born in Buenos Aires, the son of Francisco López Osornio and Tomasa Merlo, belonging to an illustrious family of landowners.

[4] He was married to Margarita Sosa, belonging to old Creole families of Portuguese roots.

[6] He was the uncle of Clemente López de Osornio, a known military man and landowner killed during an indigenous raid on his ranch, and relative to Casimiro Alegre.