In 2012, he was suspended for the first three games of the season for a violation of the NFL substance abuse policy, then restored to the active roster.
In the 2015 season, he finished with one sack, 47 total tackles, and one pass defended in 14 games.
[10] On September 10, 2017, in the season opener against the New York Jets, he recorded a career-high 12 tackles in the 21–12 victory.
[11][12] He played in 13 games with nine starts, recording a career-high 89 tackles, which finished third on the team.
[18] Humber helped the Patriots reach Super Bowl LIII where they beat the Los Angeles Rams 13–3.