A member of the Sisodia dynasty, he controlled parts of present-day Rajasthan, Gujarat and Madhya Pradesh with his capital at Chittor.

The Mughal historian Abd al-Qadir Badayuni called Sanga the bravest of all Rajputs along with Prithviraj Chauhan also known as Rai Pithaura.

[7] He united several Rajput rulers for the first time since the Second Battle of Tarain and marched against the invading forces of Babur, who founded the Mughal Empire.

Despite initial success at Bayana,Sanga suffered a major defeat at the Khanwa through Babur's use of gunpowder weaponry, which was unknown in northern India at the time.

However, due to the circumstances and after a fierce struggle with his brothers Prithviraj and Jagmal, in which he lost one of his eyes, he finally succeeded throne of Mewar in 1509.

Babur further said, "Sanga had recently grown so great by his audacity and sword that his kingdom included a significant portion of Northern India.

[14] In his illustrious military career, Sanga defeated the Sultans of Delhi, Malwa and Gujarat in 18 pitched battles and expanded his domain by conquering much of present-day Rajasthan.

[20] After the victory and establishing Hindu rule in eastern and northern Malwa, Sanga ordered Rai to remove Jizya tax from Hindus of the region.

[21][need quotation to verify] After conquering Malwa, Sanga turned his attention towards northeastern Rajasthan which was then under the control of Ibrahim Lodi, the sultan of Delhi.

[22] Lodi, reportedly stunned by this Rajput aggression (the extent of which was unprecedented in the preceding three centuries), once again moved against Mewar in 1518-19 but was humbled again at Battle of Dholpur.

The main reason for Sangas involvement in these battles was to reinstate Rai Mal to his rightful throne and to weaken the growing power of the Gujarat Sultanate.

In 1520, Sanga invaded Gujarat on the question of the succession of the state of Idar, with his powerful army of 40,000 Rajputs supported by his three vassals.

[4][26] On 21 April 1526, the Timurid king Babur invaded India for the fifth time and defeated Ibrahim Lodhi in the First Battle of Panipat and executed him.

Sanga was struck by an arrow in mid-battle and was removed from the battle by his brother-in law Prithviraj Kachwaha of Amber along with prince Maldev Rathore in an unconscious state.

Following his victory, Babur ordered a tower of enemy skulls to be erected, a practice formulated by Timur against his adversaries, irrespective of their religious beliefs.

According to historian Andre Wink, after the victory at Khanwa, the centre of Mughal power became Agra instead of Kabul and continued to remain so until its downfall after Ālamgir's death.