The original hospital was designed by Alexander Tod and opened on 28 August 1909.

[2] In the 1960s, a major extension to the south of the hospital, designed by John Holt, was completed.

[3] During the 1990s, general surgery services were transferred to the Victoria Hospital in Kirkcaldy.

[4] The most recent upgrade, costing £4.45 million, was completed and opened by Nicola Sturgeon, MSP and Health Secretary, on 16 June 2008.

[6] Randolph Wemyss Memorial Hospital serves as a clinical placement location for nursing students from the University of Dundee[7] and also provides teaching facilities for the University of St Andrews.