He returned to Argentina and joined the team of Dr. Federico Leloir undertaking important research that was influential in the work for the Nobel Prize with which he was honored.

[1] In 1963 he joined the Faculty of Chemical Sciences of the National University of Córdoba where he began an active area of research in Biological Chemistry.

His main line of research was related to brain lipids, but he also made important contributions on other topics.

[3][4] Caputto actually initiated this project by presenting some preliminary results indicating that mammary gland homogenates could produce lactose when incubated with glycogen.

[5] Ranwel's father Salvador Caputto (1886-1939) was founder of El Litoral, a popular Argentine newspaper.