Sai Kishore played his first international match against Nepal on 3 October 2023 in the Asian Games Men's Cricket.

[5] In the 2020 IPL auction, he was bought by the Chennai Super Kings at a base price of ₹20 lakh for the 2020 Indian Premier League.

[6][7] He was bought by the Gujarat Titans at a price of ₹3 crore in the 2022 Indian Premier League (IPL) auction.

[10] Following a positive case for COVID-19 in the Indian team, Kishore was added to India's main squad for their final two Twenty20 International (T20I) matches of the tour.

[12] He played in the Indian squad for the 2022 Asian Games held in Hangzhou, China and won the Gold medal.