The Rawhide Mountains border the much smaller Artillery Mountains southeast, bordering on Alamo Lake State Park and the south-flowing Big Sandy River.

The southern perimeter of the Rawhide Mountains is the west-flowing Bill Williams River.

The major mountain block at the intersection of this region west in California is the Whipple Mountains of southeast California, in the northeast Colorado Desert (the northwestern Sonoran Desert).

The northwest of the range consists of the Aubrey Peak Wilderness, of 15,400-acre (6,232 ha).

It is accessed by unimproved dirt roads, which are on the southwest and southeast perimeter.