The southern end of the range extends approximately one mile into the northwestern Mexican state of Sonora on the northern perimeter of the Gran Desierto de Altar.

The waterholes figured prominently in the history of the area as they were for many years the only reliable source of water for many miles.

Native Americans, principally the Hia C-eḍ O'odham, also utilized the waterholes as an important camp prior to European settlement.

The subdivision is characterized by minimal precipitation, and the area around the Tinajas Altas Mountains averages only about three inches of rainfall per year.

Among the notable flora present is the elephant tree, (Bursera microphylla), which species exhibits a contorted multi-furcate architecture.