The range lies mostly in Pima County with only the northernmost end extending into southern Pinal County The range lies 25 mi west of Marana, and 25 mi south of Eloy–Casa Grande, all cities on Interstate 10 in Arizona.

Casa Grande also begins the west route of Interstate 8 to Yuma and San Diego.

The West Silver Bell Mountains are a small, low elevation range, in eastern regions of Arizona's Sonoran Desert.

Lower elevation regions west or southwest are even more arid, as the Sonoran Desert gets closer to the Gran Desierto de Altar in northwestern Mexico.

The southwest end of the Sawtooth Mountains of Pinal County lies 10 km (6 mi) to the northwest.