The national park's biological value is defined by its combination of rivers, forests, mangroves, estuaries, beaches, coral reefs, wildlife, and marine life.

Ream National Park constitutes the south-east of Prey Nob district of the Sihanoukville Province bordering the Gulf of Thailand.

Between the hills and the estuary of the Prek Teuk Sap lies a narrow discontinuous belt of wetlands.

[3] Wildlife found or reported in the national park includes, but is not limited to: rhesus monkeys, dugongs, turtles, dolphins, mouse-deer, Sarus crane, and pelicans.

Almost 30,000 people or 5,500 households live in the five communes that overlap or border Ream National Park, and population growth rates are estimated at nearly 3%.

[7][8] A wide range of groups and individuals have converging and diverging interests or stakes in the park's resources.