Humphries attended London Academy of Music and Dramatic Art and has appeared on stage in productions of Temple at the Donmar Warehouse, Pomona at the National Theatre and Blackout Songs at the Hampstead Theatre.
[1] Humphries' comedy television roles have included Friday Night Dinner and Morgana Robinson's The Agency.
She played Julie Fincham in the Amazon Prime Video series Ten Percent, a British remake of Call My Agent!, in April 2022.
[6] Humphries began a relationship with British comedian Seann Walsh in 2013 which lasted for five years.
She has spoken in the House of Commons about gaslighting and the media on behalf of the organisers of the Women’s March London.