A second series began publication in December 2016, being set in Archie Comics New Riverdale universe with a new character design aesthetic and a more mature story format and scripting, aimed for older, contemporary teenage and young adult readers.
During this publication period a second series, Reggie's Wise Guy Jokes, ran for 60 issues between August 1968 and January 1982.
On September 20, 2016, it was announced that a reboot of Reggie and Me would be published as part of Archie Comics' New Riverdale lineup.
The series "promises to give readers an inside look at the most loved, revered, admired and adored teen in Riverdale".
[1] Series writer Tom DeFalco said “Reggie Mantle has been called a self-aggrandizing egotist, a sinister super-villain, a merciless monster and worse, but his dog loves him.