At about 4:50 p.m., green funnel clouds formed and touched down south of the city, tearing through the residential area between Wascana Lake and Victoria Avenue, and continuing through the downtown business district, rail yards, warehouse district, and northern residential area.

[1] The tornado's wind velocity has been estimated at 400 kilometres per hour (250 mph),[citation needed] making it the equivalent of a high-end F4 on the Fujita Scale.

The tornado also displayed a multiple vortex structure throughout the city's residential areas, leaving individual houses untouched next to homes that were completely flattened.

The tornado formed 18 km south of the city and was roughly 150 metres wide by the time it reached Regina.

The worst damage was in the residential area north of Wascana Lake and the central business district.

Boris Karloff, Jeanne Russell, Henrietta Crosman, and the Albini-Avolos are all characters in BD Miller's musical drama, "Swept Off Our Feet: Boris Karloff and the Regina Cyclone", which commemorated the 100th anniversary of the disaster and premiered as a July 2012 production of Regina Summer Stage.

[8] The novel Euphoria by Connie Gault won the 2009 Saskatchewan Book Award for Fiction and prominently features the Regina Cyclone.