After being a professor of canon law at Quartier de la Sorbonne, Paris for many years, Reginald became dean of the collegiate church of Saint-Agnan in Orléans.

[1] In 1216, he decided to follow Bishop Manasses de Seignelay who was to meet Pope Honorius III in Rome, before making a pilgrimage to Jerusalem.

At the University of Bologna, many students and professors were deeply impressed by Reginald's preaching, including Maestro Moneta and Roland of Cremona, who rushed to the friars on an Ash Wednesday to ask them to enter the Dominican order.

[1] In Paris, Reginald became prior of the Dominican convent of Saint-Jacques and, with his sermons, he enthused many professors at the Sorbonne as well as many students, among whom were Jordan of Saxony, who would be Dominic's successor in the Order.

Today, an altar exists in the crypt of Notre-Dame-des-Champs on rue Pierre-Nicole where it is written that "for centuries the Parisians came to honor him and pray to him in this sanctuary".