It was initially conceived as a celebration of Velasquez's 35th anniversary since her professional debut, and was promoted as the lead-up event following her concert residency Solo at the Samsung Performing Arts Theater, which ran from February to April 2023.

The show spans over 2.5 hours, with a set list of 33 songs, including music from rock artists such as Aerosmith, Bon Jovi, Coldplay, Guns N' Roses, Led Zeppelin, Nirvana, Queen, Radiohead, and the Rolling Stones.

Yeng Constantino, Klarisse de Guzman, Morissette, and Jona Viray performed as guest acts for the opening night, while Darren Espanto and Juan Karlos Labajo were selected for the final date.

Regine Rocks received generally positive reviews from music critics, with particular praise for the production value and artistic direction, as well as Velasquez's showmanship and vocal performance.

[3] She has previously performed anniversary shows celebrating her 20th, 25th, and 30th career milestones: Twenty staged at the Araneta Coliseum in 2006, Silver in 2012, and R3.0 in 2017, the latter two held at the Mall of Asia Arena.

[15][16] Valenciano's objective was "to make everyone feel like Regine was in her prime, just by the stage design", drawing comparison to Velasquez's concert residency, Solo, which he described as "more minimalist".

[15] During the first show, Velasquez invited special guest performers such as Yeng Constantino, Klarisse de Guzman, Morissette, and Jona Viray.

The concert opened with Velasquez, in a black bodysuit and metallic blazer, descending from an iron throne-inspired platform and singing excerpts from Queen's "Who Wants to Live Forever" (1986).

She sat at the elevated platform with a staircase on the main stage for a stripped-down rendition of the Eraserheads's 1996 song "Ang Huling El Bimbo".

Then, Velasquez honored American rock band Heart by performing a medley of their songs alongside Klarisse de Guzman, Morissette, and Jona Viray.

She reappeared on stage and closed the concert with an encore performance of the Filipino rock songs "Liwanag sa Dilim" (2003) and "Hallelujah" (2005).

Velasquez continued to perform covers of Filipino rock musicians, adding Teeth's "Laklak" (2006) and Yano's "Banal Na Aso, Santong Kabayo" (1994).

[18] The writer Ogie Narvaez Rodriguez from Abante acknowledged that Velasquez's concert lived up to expectations, with praise centering on her showmanship and vocal abilities.

[14] Writing for Billboard Philippines, Kara Angan commended the first show's production value and artistic direction, highlighting its theme and stage design.

[12] In her review of the final show, Angan continued to emphasize the versatility of its music, visuals, and performance art, complimenting Velasquez's stage presence and commitment to her artistry.

She declared Regine Rocks as a "jaw-dropping" spectacle and concluded: "It's a tall order for any performer—classically trained or not—to fill ... but she made it look like a walk in the park".