Guest conductors were featured, including Louie Ocampo and Gerard Salonga, backed by the 60-member ensemble of the Manila Philharmonic Orchestra.

[5][7] On September 24, 2006, the Philippine Daily Inquirer published that Velasquez would headline a two-night concert to celebrate the 20th anniversary since her career debut.

Several guest conductors also made special appearances during the show, including Louie Ocampo, Gerard Salonga, Mark Lopez, and Mon Faustino.

The stage set up was built to resemble a Roman colosseum and featured a grand staircase extending from the upper box gallery.

[2] The concert opened with Velasquez performing an operetta musical number telling the story of her career beginnings, before transitioning to "Narito Ako".

Shortly after, she began a medley of "Hot Stuff" and "Shake Your Groove Thing" which contained samples of The Pussycat Dolls's "Buttons" and Don't Cha.

For the next number, Velasquez sang the movie theme song "Music of Goodbye" while aerialists performed acrobatics.

[9] The setlist continued with guest conductor Mon Faustino at the helm of Velasquez's performance of "Sana Maulit Muli".

[10] Jojo Panaligan from the Manila Bulletin wrote, "Regine has reached twenty years in the business because others, from past to present, could only approximate the power and impact of her voice.

[9] Velasquez was named Best Female Major Concert Act and Entertainer of the Year at 20th Aliw Awards for the production.