Filmed at Velasquez's Ayala Hillside Estates residence in Quezon City, the two-hour special was directed by Louie Ignacio, while Raul Mitra served as the music director.

The program featured guest stars Ogie Alcasid, Jay R, and Kyla, and a special performance with the singer's parents.

Velasquez performed a selection of cover songs from rock bands, such as the Eagles and U2, as well as music from Colbie Caillat, David Foster, Josh Groban, and Kenny Loggins.

In April 2008, a two-hour television special entitled The Best of Me was conceived to celebrate Filipino recording artist Regine Velasquez's 38th birthday.

[2] The special was described in a press release as "a totally different facet of Asia's Songbird", which would feature songs the singer has been "itching to perform onstage but never really got a chance because it is not what the audience expects".

[3] A promotional tie-in with the special was the premiere performance of the movie theme "Babae", from the animated film Urduja (2008),[2][3] for which the eponymous title character was voiced by Velasquez.

[4] Principal photography took place at Velasquez's Ayala Hillside Estates residence in Quezon City, which was completed in November 2007.

I didn't agree with the idea then because I wanted to keep a little bit of privacy but when I learned it's hard to book the show in the hotel, I thought it would be best to do it in the house.

[8] The show began with Velasquez, perched at the balcony of her three storey residence wearing a silk dress and jeans, singing the first few verses of David Foster's "The Best of Me".