Reinhold Frank was born the youngest of seven children in Bachhaupten in the Sigmaringen district.
He often found himself defending persecuted clients of all political and religious stripes, among them Catholic priests, who often ended up before the courts during the time of the Third Reich for having uttered criticisms of the régime.
Reinhold Frank belonged to the circle about the resistance group founded by Dr. Carl Friedrich Goerdeler.
He had already agreed to stand ready in Baden to take a leading role in Germany's reconstruction, should the plot to overthrow Hitler actually succeed.
The Research Centre for German Resistance against National Socialism in Southwestern Germany, together with the University of Karlsruhe, the City of Karlsruhe, and the German Bundesarchiv, honours Frank yearly in the time around 20 July with a memorial reading.