In the mid-1960s, after reading a rather violent White Cartoon French book, he decided to open a publishing house in Milan and developed the idea of "pocket comics", also known as a digest.
In 1966 he created Editore 66, inspired by film and literary subjects of the time (such as Angelica and James Bond) and developed the plots of his first two comics books, Isabella and Grendizer (both illustrated by Sandro Angiolini).
Initially slightly erotic in terms of contents, the books became progressively more pornographic towards the end of the 1970s, reflecting the sexual revolution and the increasing permissiveness in the press and in film taking place in Italy at the time.
Under the new banner of Edifumetto, Barbieri created some of the most notable titles of the horror and soft porn comics genre, including Zora la Vampira, Rolando del Fico, Cimiteria, Vampiro, Scheletro, Sukia Belzeba, Playcolt, Mafia, Poppea, Necron, and dozens of other characters.
Their success was due in large part to the covers painted by classically trained artists such as Alessandro Biffignandi, Emanuele Taglietti, Roberto Molino, Pino Dangelico, Enzo Sciotti, and Carlo Jacono.