It was founded on 1 September 2021 as the Research Organization for Life Sciences (Organisasi Riset Ilmu Pengetahuan Hayati, ORIPH) transformation of Deputy II (Life Sciences) of Indonesian Institute of Sciences (Lembaga Ilmu Pengetahuan Indonesia, LIPI) after the liquidation of LIPI into BRIN.

[1] On 24 January 2022, it was announced that the organization extended with a fusion of the ORIPH with FORDA-MOF of the Ministry of Environment and Forestry, resulting in the formation of ORIPHL.

[5] In addition to the preexisting research centers, ORIPH also housed the Eijkman Institute for Molecular Biology after BRIN acquired it on 22 September 2021.

[9] As ORIPH, the organization briefly served as a temporary house of the Eijkman Molecular Biology Research Center.

[2] On 4 March 2022, ORIPHL was fully functional with the inauguration of its first head, Iman Hidayat.