[1] A P. falciparum protein complex called PfRH5-PfCyRPA-PfRipr (RCR) is known to bind basigin via the tip of RH5.
[3] The trimeric complex forms an elongated structure with RH5 and Ripr on distal ends and CyRPA in the middle.
[4] The RCR complex has been identified as a promising malaria vaccine target with each individual component capable of inducing strain transcending immunity in in vitro assays of parasite growth.
[7] RHs do not express any significant sequence feature for specific domains, except for a set of transmembrane helices at the C-terminal.
The structure of the EBD has been experimentally observed in 2011 by small angle X-ray scattering.