He held a postdoctoral fellowship at the University of California, San Francisco, then an assistant professorship at Mount Sinai School of Medicine, City University of New York, and then joined the Scripps Research Institute, La Jolla, working with Richard Lerner.
[5] Because traditional methods of chemical discovery and selection relied on "natural" pathways (those formed by sources found in the wild and brought into the library), creation of the requisite number of peptides for new drug discovery was impractical.
[8] By another variation, "split and mix", tens of millions of very diverse peptides can be made, and then assayed by some technique.
Very precise deconvolution of the results, or alternatively, marking the peptide beads, can correlate sequence and activity.
[2] The problem of generating and sequencing large libraries of peptides suitable for pharmaceutical work remained.