He performed his postgraduate training in New York City at St. Vincent's Hospital (Manhattan), where he completed his internship.
He is a Clinical Professor of Neurology at George Washington University School of Medicine & Health Sciences.
As a regular lecturer, both nationally and internationally, he has presented commentaries for both Morning Edition and All Things Considered on National Public Radio and made numerous appearances on leading television talks shows including: the Today Show, Good Morning America, the Discovery Channel, and the PBS NewsHour.
He has appeared as an expert witness for the defense in the high-profile trial of Mir Aimal Kasi, the Pakistani national charged with the 1993 shootings at CIA headquarters in Langley, Virginia.
During the trial Restak testified that Kasi was missing tissue from his frontal lobes, a congenital defect that affected his ability to judge the consequences of his actions.