He was also the head of a thriving workshop whose pupils included Michele Tosini (also known as Michele di Ridolfo), Domenico Puligo, Bartolomeo Ghetti, Antonio del Ceraiolo, Toto del Nunziata, Mariano Graziadei da Pescia, Carlo Portelli and others.
Ridolfo was prominent in the execution of works for various public occasions, such as the wedding of Giuliano de' Medici, and the entry of Leo X into Florence in 1515.
In addition to painting, Ridolfo also experimented with mosaics, but it seems that only one such work, the Annunciation over the door of the Santissima Annunziata, survives today.
Ridolfo's masterpieces include a number of altarpieces, including the Madonna della Cintola (1503–09) over the door of the cathedral in Prato; the Way to Calvary for the church of San Gallo, Florence (now London, National Gallery); the Coronation of the Virgin (1504), originally at San Jacopo di Ripoli, Florence, and now at the Musée du Petit Palais, Avignon; and the Nativity for the cathedral in Basel, Switzerland, and now at the Museum of Fine Arts in Budapest.
These include images of the Trinity surrounded by the heads of the twelve apostles and other accessories, a lunette of the Annunciation and another with the Vision of Saint Bernard.
These panels, now at the Galleria dell'Accademia in Florence, originally flanked a large Annunciation by Mariotto Albertinelli, now also at the Accademia.