Rios Blanco y Negro Wildlife Reserve (Spanish: Reserva de Vida Silvestre Ríos Blanco y Negro, RVSRByN) is a departmental protected area in Ñuflo de Chávez and Guarayos provinces in the northern part of the Bolivian department of Santa Cruz.
Living in the vicinity of the protected area are the native Guarayo and Chiquitano peoples, who engage in such diverse traditional activities as berry picking, subsistence hunting and fishing, and farming.
The San Pablo and Blanco Rivers are rich in nutrients and cause seasonal flooding in the areas closest to the plains, forming the so-called "Várzea forest", which regulate the rise and fall of the water levels.
The natural flood cycle in the reserve zone is essential to the maintenance of the Baures and Magdalena wetlands in Beni, in northern Bolivia.
The primary threats to the integrity of the reserve are: The activities cause degradation of the forest's structure, leading to the loss of species of animal and plant life.