Ripe San Ginesio is a comune (municipality) in the Province of Macerata in the Italian region Marche, located about 50 kilometres (31 mi) south of Ancona and about 20 kilometres (12 mi) southwest of Macerata.

Ripe San Ginesio borders the following municipalities: Colmurano, Loro Piceno, San Ginesio, Sant'Angelo in Pontano.

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