There was a gap of six years between Till Death Do Us Part and Rise Up, the longest between studio albums of Cypress Hill's recording career at the time of release.

Featured guests include Daron Malakian of System of a Down, Pitbull, Everlast, Evidence, Young De, Tom Morello of Rage Against the Machine and Audioslave, and Marc Anthony.

[7][8] The album's introduction single, "It Ain't Nothin'" was released as a free download from the group's official website with a music video by Matt Alonzo.

"Rise Up", with Tom Morello, is the second single; it also features as the theme song for Elimination Chamber 2010 and the end-credit track for the Season 3 finale episode of the television show Silicon Valley.

"[11] An early review, Scottish magazine The Skinny offered a largely positive 3 stars (out of 5), noting that the album appears "less playful than its predecessor (2004’s Clash-sampling Till Death Do Us Part) but surprisingly more focused - given Muggs’ notable absence from the producer's chair – [The Hill] source inspired collaborations with Pete Rock, Jim Jonsin and Marc Anthony to reinforce their timeless agenda."