[10] Butcher began his comedy career performing improv in Chicago at The Second City and has since performed stand-up at clubs including Zanies, the Jukebox, and Flappers, as well as Chicago Underground Comedy, The Hideout, The Lincoln Lodge, UCB, Cole's, and Meltdown.

[13][14] In the fall of 2014, Butcher appeared alongside Cameron Esposito in a series of videos for BuzzFeed Motion Pictures titled "Ask a Lesbian".

[15][16] Butcher and Esposito also co-hosted the web series "She Said" for Amy Poehler's Smart Girls Network.

[18][19] Butcher also co-hosted the stand-up comedy podcast Put Your Hands Together with Cameron Esposito, which was recorded weekly in front of a live audience at the Upright Citizens Brigade Theater in Los Angeles until it ended in July 2019.

[20][21][22] His first comedy album Butcher was released in August 2016 by the independent record label Kill Rock Stars.

[27] As stated in an interview, Butcher said his strongest comedy influences are Rosie O'Donnell, Ellen DeGeneres, Brett Butler, Elayne Boosler, Maria Bamford, and Paul F.

[28] Butcher provided the voice for Asher, a fictional nonbinary character, for the animated series Kipo and the Age of Wonderbeasts, released in 2020.