The show follows former real-life couple Cameron Esposito and River Butcher as they share their lives as stand-up comics who are balancing work, relationships, and the breaking down of gender barriers.

[2] On August 9, 2017, Seeso announced the shutdown of its service by the end of the year, leaving Take My Wife without a home.

[3] For its second season, the show's creators and producers featured large numbers of women, people of color, and LGBTQ individuals in front of and behind the camera.

[4][5] Esposito has acknowledged this was a conscious effort on their part: "As a small budget show, we prioritized hiring queer folks, POC, and female standups.

A web campaign to "#SaveTakeMyWife" quickly formed to encourage another network or streaming service to pick up the show for future seasons.