However, the most significant structure in the group, the Parke-Davis Research Laboratory, is individually recognized as a National Historic Landmark.

The Research Laboratory was built in 1902 after Parke-Davis relocated the Detroit Boat Club to Belle Isle.

[7] Omni closed the hotel in 2010, and it was acquired by St. Louis real estate developer Michael V.

[10] In 2002, National Park Service staff recommended withdrawal of the site's landmark status due to loss of the building's historic integrity during the conversion.

[11] This building was the first industrial research laboratory in the U.S. established for the specific purpose of conducting pharmacological research, inaugurating the commercial pure science approach which has driven the rapid development of pharmaceutical technology.