The Rivière Port-Daniel du Milieu flows in the administrative region of Gaspésie–Îles-de-la-Madeleine, Quebec, Canada.

More specifically, this river crosses successively: The "Rivière Port-Daniel du Milieu" is a tributary of the north shore of the barachois of the hamlet of "Rivière-Port-Daniel" which opens to the south in the bay of Port-Daniel, located on the North shore of Chaleur Bay; the latter in turn opens eastward onto the Gulf of St. Lawrence.

This source of the river is located at: From its source, the "Rivière Port-Daniel du Milieu" flows on 24.6 km (15.3 mi) towards the South, then the South-East, especially in forest and mountainous areas, divided into the following segments: The “Rivière Port-Daniel du Milieu” flows onto the north bank of the barachois in the hamlet of “Rivière-Port-Daniel du Milieu”, crossing the sandstone at low tide.

These two strips of land are linked by the Canadian National railway bridge and by route 132.

This bay, the width of which at the opening is 2.8 km (1.7 mi), is delimited by the "Cap de la Vieille" (on the east side) and by the Pointe du Sud-Ouest.