He later worked for Fast Company as a video blogger, and then Rackspace and the Rackspace-sponsored community site Building 43 promoting breakthrough technology and startups.

Impressively, he has also succeeded where small armies of more conventional public-relations types have been failing abjectly for years: he has made Microsoft, with its history of monopolistic bullying, appear marginally but noticeably less evil to the outside world, and especially to the independent software developers that are his core audienceOn June 10, 2006, Scoble announced[10] he was leaving Microsoft to join Podtech.net as vice president of media development with a higher salary accompanied by "a quite aggressive stock option"[11] offer that would have made him wealthy if his new company had succeeded.

On December 11, 2007, while taking part in a panel discussion at the LeWeb3 Conference, he inadvertently leaked news (by loading up a post on TechCrunch) that he would be leaving PodTech on January 14, 2008, and was likely to join Fast Company.

As part of his work there, he teamed up with the company to develop Building 43, a new content and social networking website aimed to help grow new startups and promote groundbreaking technology.

[18] On October 20, 2017, the news outlet BuzzFeed published a story that alleges that in 2010, Scoble sexually assaulted Michelle Greer, his Rackspace coworker, and Quinn Norton, a technology journalist.

Scoble and Israel talked to their book titled "Age of Context: Mobile, Sensors, Data and the Future of Privacy".

[26] On November 14, 2007, he was a contestant on a game show at NewTeeVee Live[27] featuring other internet celebrities such as Veronica Belmont, Casey McKinnon, Cali Lewis, Kevin Rose, Justin Kan, and others.

[28] On November 6, 2006, Scoble appeared as a panelist on a Chinese Software Professionals Association event called "The New Age of Influence: The Impact of Social Computing on Media and Marketing".