He made it to the tournament's semifinals after beating former top-ten players, Tommy Robredo, Fernando Verdasco, and an in-form Barcelona finalist Santiago Giraldo en route to this stage.

Bautista Agut won his first ATP title there, defeating former champion Benjamin Becker in the final in three sets.

After defeating Steve Johnson and Jan Hernych, his run ended at the hands of the defending champion Andy Murray in the third round.

In the semifinal, Bautista Agut recorded an upset, beating defending champion Fabio Fognini for the second time in his career.

[8] In the US Open, Bautista Agut reached the fourth round, after defeating Andreas Haider-Maurer, Tim Smyczek, and Adrian Mannarino on the way to taking on the No.

After victories over Pierre-Hugues Herbert, Pablo Carreño Busta, and David Goffin, he reached the fourth round of a major for a second consecutive time.

He was the second seed in the Kremlin Cup, and in a repeat of the previous years final, Bautista Agut lost against Marin Čilić by the same scoreline (4–6, 4–6).

He earned his first ever win over Čilić in a shock straight-sets result setting up a match-up with the sixth seed, Tomáš Berdych.

He reached the fourth round of the French Open after he defeated Dmitry Tursunov, Paul-Henri Mathieu, and Borna Ćorić.

His quest for a place in a Grand Slam quarterfinal was again ended by a top-ten player, this time by world number one, Novak Djokovic.

He advanced to the quarterfinals in Rio de Janeiro after beating Andrey Kuznetsov, Paolo Lorenzi, and Gilles Müller in the earlier rounds.

Later that month, Bautista Agut reached the final of the Winston-Salem Open in which he lost to compatriot Pablo Carreño Busta in three sets.

In the penultimate Masters 1000 event of the year, the Shanghai Masters, Bautista Agut made it to his first Masters-1000 final, defeating Bernard Tomic (who was forced to retire because of abdominal pain[14]), qualifier Taylor Fritz, Viktor Troicki, 2015 finalist Jo-Wilfried Tsonga, and top seed and defending champion Novak Djoković.

In the final, Bautista Agut beat Daniil Medvedev in straight sets, securing his fifth career title.

Bautista Agut caused an upset beating Nishikori for the first time and claiming his seventh top-ten scalp of his career.

In the final, Bautista Agut took on second seed Juan Martín del Potro, who had yet to drop a set in the tournament.

He went on to beat his opponent in three sets, clinching his second Auckland title, and ending a three-match losing streak against the tall Argentine.

In March, he won his biggest title yet in the ATP 500 tournament in Dubai, losing only one set along the way and beating in-form Lucas Pouille in the final.

[17] In the quarterfinals, he was defeated by 14th seed Stefanos Tsitsipas,[18] who was fresh off a victory over defending champion Roger Federer, in four sets.

He beat Tennys Sandgren for his 300th career win[21] and Miomir Kecmanović before being upset in the third round by Canadian Vasek Pospisil.

Bautista Agut made two finals in the early hardcourt season in Montpellier and Doha, where he was defeated by David Goffin and Nikoloz Basilashvili respectively.

[22][23] To reach the final in Doha, Bautista Agut beat two top ten players, Dominic Thiem and Andrey Rublev.

Seeded 8th, he reached the fourth round at the 2021 Wimbledon Championships defeating John Millman, Miomir Kecmanović and Dominik Koepfer before losing to eventual semifinalist Denis Shapovalov.

Bautista Agut has played a pivotal role in Spain's 2022 ATP Cup journey, by winning all of his three singles matches in the group stage.

In the final, Bautista Agut suffered the decisive loss to Félix Auger-Aliassime as Team Canada won the title.

Bautista Agut reached the final of the 2022 Qatar ExxonMobil Open in Doha again to set a rematch with Nikoloz Basilashvili.

[28] In October at the 2022 Astana Open he defeated eight seed Félix Auger-Aliassime[29] and lucky loser Pavel Kotov to reach the quarterfinals.

[35] Seeded fourth at the Open Sud de France, Bautista Agut lost in the second round to French wildcard Arthur Fils.

[51] He recorded his 400th career win at the 2024 Barcelona Open Banc Sabadell over lucky loser Andrea Vavassori in the second round.

[52] Bautista Agut won his 12th ATP Tour singles title at the European Open in Antwerp, Belgium, in October, defeating Jiří Lehečka in the final.