Stefanos Tsitsipas defeated Roberto Bautista Agut in the final, 6–4, 3–6, 7–6(7–2) to win the singles title at the 2022 Mallorca Championships.

Daniil Medvedev was the defending champion, but lost in the quarterfinals to Bautista Agut.

[1] The top four seeds receive a bye into the second round.