[citation needed] He created two hugely popular comic strips, as well as their parodic protagonists: Inodoro Pereyra, a gaucho, and Boogie, el aceitoso, a gun-for-hire.

In 2013 an Argentine animated film directed by Juan José Campanella and loosely based on Fontanarrosa's short story "Memorias de un wing derecho" was released to box office success.

His most famous strips are Inodoro Pereyra, featuring a gaucho and his talking dog Mendieta, and the hitman Boogie el Aceitoso, which came to life as a Dirty Harry parody.

His work has been seen in different Latin American newspapers including Argentine Clarín, Colombian El tiempo, Uruguayan La República, and Mexican magazine Proceso.

In November 2007, a posthumous work of Fontanarrosa was made public: the animated film Fierro was released, for which he had co-written the script and designed all the characters shortly before his death.

[2] He continued to work, and participated in the meetings of the Third International Congress of the Spanish Language, in 2004, where he gave a humorous lecture about taboo words and the final speech.