He played in MLB for the Tampa Bay Rays, Texas Rangers, Houston Astros, New York Mets, Chicago Cubs, and Baltimore Orioles.

The following season, Chirinos played for the Single-A Peoria Chiefs, posting a .242/.360/.383 batting line with career-highs in home runs (9) and RBI (47).

For the 2007 season, Chirinos split the year between the Double-A Tennessee Smokies and Daytona, and hit a cumulative .246/.357/.358 in 121 games between the two teams.

The next season, Chirinos played for Tennessee, Daytona, and the AZL Cubs, accumulating a .275/.394/.441 slash line with 5 home runs and 29 RBI between the three teams.

In 2010, Chirinos split the year between Tennessee and the Triple-A Iowa Cubs, hitting a cumulative .326/.416/.583 with even newer career-highs in home runs (18) and RBI (74).

[3] On January 8, 2011, Chirinos was traded to the Tampa Bay Rays alongside Sam Fuld, Hak-Ju Lee, Brandon Guyer, and Chris Archer in exchange for Matt Garza, Fernando Perez, and Zac Rosscup.

[7] Chirinos had an opportunity to make the big league club in 2012 out of spring training, but he suffered a concussion which prevented him from playing any baseball during the 2012 season.

Chirinos, thinking that the collision was intentional, scolded Kemp for colliding into him, and the two fought, leading to the benches clearing.

[7] Chirinos allowed 53 stolen bases, fourth-most for a catcher in the AL, as he caught 6 runners, for a caught-stealing percentage of 10%.

On February 15, 2021, Chirinos signed a minor league contract with New York Yankees organization that included an invitation to Spring Training.

[14] On March 10, 2021, in a game against the Pittsburgh Pirates, Chirinos was hit in the hands by a Blake Cederlind pitch and was later diagnosed with a fractured right wrist.

[15] On March 15, Yankees manager Aaron Boone told reporters that Chirinos would undergo surgery the next day on his broken wrist and miss four to six weeks.