The Roman Catholic Archdiocese of Antofagasta (Latin: Antofagasten(sis)) is a Latin Rite Metropolitan archdiocese in northern Chile's Antofagasta Province.

As per 2014, it pastorally served 386,017 Catholics (70.2% of 550,256 total) on 84,504 km2 in 20 parishes and 67 missions with 37 priests (18 diocesan, 19 religious), 28 deacons, 108 lay religious (24 brothers, 84 sisters) and 2 seminarians.

The Metropolitan's Suffragan sees are : (all Roman rite Chileans)

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